Hydroxylamine → 5-[5-(Hydroxycarbamoyl)pentyl]-imidazo[1,5-a]-pyridine

HRID 2417834ノート

反応式

HRID 2417834 の反応式
[NH2:1][OH:2].C[O:4][C:5]([CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][C:12]1[N:17]2[CH:18]=[N:19][CH:20]=[C:16]2[CH:15]=[CH:14][CH:13]=1)=O>CO>[OH:2][NH:1][C:5]([CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][C:12]1[N:17]2[CH:18]=[N:19][CH:20]=[C:16]2[CH:15]=[CH:14][CH:13]=1)=[O:4]

参加物

4

反応物 2

HCID 787HydroxylamineHCID 233218845-(5-Methoxycarbonylpentyl)imidazo[1,5-a]pyridine

生成物 1

HCID 133736345-[5-(Hydroxycarbamoyl)pentyl]-imidazo[1,5-a]-pyridine

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

A solution of hydroxylamine (from 2.06 g of hydroxylamine hydrochloride and 2.02 g of sodium hydroxide) and 5-(5-methoxycarbonylpentyl)imidazo[1,5-a]pyridine (6.08 g) in 25 ml of methanol is allowed to stand at room temperature for 20 hours. The methanol is evaporated and the residue is taken up in 5 ml of water and adjusted to pH=7. The resulting oil crystallizes and the solid is collected, yielding 5-[5-(hydroxycarbamoyl)pentyl]-imidazo[1,5-a]-pyridine, m.p. 138°-140°.

後処理

  1. customThe methanol is evaporated
  2. customThe resulting oil crystallizes
  3. customthe solid is collected

出典と根拠

ORDレコード
ord-ba7f7f75a787447596fc5eacff0115a7
出典データセット
uspto-grants-1984_09
特許番号
US04470986

反応ノート

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