Acetic Anhydride → 4-Acetamidophenyl 4-O-(alpha-D-glucopyranosyl)-1-thio-beta-D-glucopyranoside

HRID 2417865ノート

反応式

HRID 2417865 の反応式
[C@H:1]1([O:12][C@@H:13]2[C@@H:26]([CH2:27][OH:28])[O:25][C@@H:16]([S:17][C:18]3[CH:23]=[CH:22][C:21]([NH2:24])=[CH:20][CH:19]=3)[C@H:15]([OH:29])[C@H:14]2[OH:30])[O:9][C@H:8]([CH2:10][OH:11])[C@@H:6]([OH:7])[C@H:4]([OH:5])[C@H:2]1[OH:3].[C:31](OC(=O)C)(=[O:33])[CH3:32]>O>[C@H:1]1([O:12][C@@H:13]2[C@@H:26]([CH2:27][OH:28])[O:25][C@@H:16]([S:17][C:18]3[CH:19]=[CH:20][C:21]([NH:24][C:31](=[O:33])[CH3:32])=[CH:22][CH:23]=3)[C@H:15]([OH:29])[C@H:14]2[OH:30])[O:9][C@H:8]([CH2:10][OH:11])[C@@H:6]([OH:7])[C@H:4]([OH:5])[C@H:2]1[OH:3]

参加物

4

反応物 2

HCID 7918Acetic AnhydrideHCID 542687654-aminophenyl 4-O-(alpha-D-glucopyranosyl)-1-thio-beta-D-glucopyranoside

生成物 1

HCID 545032914-Acetamidophenyl 4-O-(alpha-D-glucopyranosyl)-1-thio-beta-D-glucopyranoside

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

A 1.0 g portion of 4-aminophenyl 4-O-(α-D-glucopyranosyl)-1-thio-β-D-glucopyranoside was dissolved in 5 ml of water and 0.340 ml of acetic anhydride was added with vigorous stirring. After stirring 10 minutes the reaction was concentrated, reconcentrated from toluene, dissolved in ethanol and precipitated with ether, giving 836 mg of the desired intermediate.

後処理

  1. concentrationwas concentrated
  2. dissolutiondissolved in ethanol
  3. customprecipitated with ether

出典と根拠

ORDレコード
ord-e85e80f0027a42138dfdf20e37984306
出典データセット
uspto-grants-1984_09
特許番号
US04470976

反応ノート

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