3-Amino-1-propanol → 1-(2-Chloro-5-nitrophenyl)-3-(3-hydroxypropyl)thiourea

HRID 2417910

反応式

HRID 2417910 の反応式
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([N+:8]([O-:10])=[O:9])=[CH:4][C:3]=1[N:11]=[C:12]=[S:13].[NH2:14][CH2:15][CH2:16][CH2:17][OH:18]>C(O)C>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([N+:8]([O-:10])=[O:9])=[CH:4][C:3]=1[NH:11][C:12]([NH:14][CH2:15][CH2:16][CH2:17][OH:18])=[S:13]

参加物

4

反応物 2

HCID 90863-Amino-1-propanolHCID 926811-Chloro-2-isothiocyanato-4-nitrobenzene

生成物 1

HCID 30187341-(2-Chloro-5-nitrophenyl)-3-(3-hydroxypropyl)thiourea収率 72%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

To a stirred solution of 24 parts of 1-chloro-2-isothiocyanato-4-nitrobenzene in 200 parts of ethanol 95% are added dropwise 9 parts of 3-amino-1-propanol at a temperature below 20° C. Upon completion, stirring is continued for 30 minutes at room temperature. The reaction mixture is evaporated. The residue is crystallized from acetonitrile. The product is filtered off and dried, yielding 23 parts (72%) of N-(2-chloro-5-nitrophenyl)-N'-(3-hydroxypropyl)thiourea; mp. 126.8° C.

後処理

  1. customThe reaction mixture is evaporated
  2. customThe residue is crystallized from acetonitrile
  3. filtrationThe product is filtered off
  4. customdried

出典と根拠

ORDレコード
ord-b508b8a7443b4001aa8c6558af803e13
出典データセット
uspto-grants-1984_09
特許番号
US04471117

関連ノート

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