Dimethylformamide → 3-((5-Nitrobenzothiazol-2-yl)amino)propanol

HRID 2417911

反応式

HRID 2417911 の反応式
Cl[C:2]1[CH:7]=[CH:6][C:5]([N+:8]([O-:10])=[O:9])=[CH:4][C:3]=1[NH:11][C:12]([NH:14][CH2:15][CH2:16][CH2:17][OH:18])=[S:13].C(=O)([O-])[O-].[K+].[K+].CN(C)C=O>O>[N+:8]([C:5]1[CH:6]=[CH:7][C:2]2[S:13][C:12]([NH:14][CH2:15][CH2:16][CH2:17][OH:18])=[N:11][C:3]=2[CH:4]=1)([O-:10])=[O:9]

参加物

5

反応物 3

HCID 6228DimethylformamideHCID 11430Potassium CarbonateHCID 30187341-(2-Chloro-5-nitrophenyl)-3-(3-hydroxypropyl)thiourea

生成物 1

HCID 30187353-((5-Nitrobenzothiazol-2-yl)amino)propanol収率 72.2%

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

A mixture of 21 parts of N-(2-chloro-5-nitrophenyl)-N'-(3-hydroxypropyl)thiourea, 10 parts of potassium carbonate and 180 parts of N,N-dimethylformamide is stirred and refluxed for 30 minutes. After cooling, 300 parts of water are added and the product is allowed to crystallize. It is filtered off and washed with water, yielding 13.3 parts (72.2%) of 3-[(5-nitro-2-benzothiazolyl)amino]-1-propanol; mp. 140°-144° C.

後処理

  1. temperaturerefluxed for 30 minutes
  2. temperatureAfter cooling
  3. customto crystallize
  4. filtrationIt is filtered off
  5. washwashed with water

出典と根拠

ORDレコード
ord-743183d9e5e54f24a5d59264d91e52a9
出典データセット
uspto-grants-1984_09
特許番号
US04471117

関連ノート

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