Methanol → Methyl 4-chloroacetoacetate

HRID 2418482ノート

反応式

HRID 2418482 の反応式
Cl[C:2]1([CH2:7][Cl:8])[O:5][C:4](=[O:6])[CH2:3]1.[CH3:9][OH:10]>C(=O)(O)[O-].[Na+]>[CH3:9][O:10][C:4](=[O:6])[CH2:3][C:2]([CH2:7][Cl:8])=[O:5]

参加物

4

反応物 2

HCID 887MethanolHCID 137182814-Chloro-4-(chloromethyl)oxetan-2-one

生成物 1

HCID 36240Methyl 4-chloroacetoacetate

試薬・触媒・溶媒 1

HCID 516892Sodium Bicarbonate溶媒

実験手順

7.8 Parts of 4-chloro-4-chloromethyloxetan-2-one are dissolved in 200 parts of methanol containing 4.2 parts of anhydrous sodium bicarbonate. After stirring for 20 hours at room temperature, the solids are filtered off, the filtrate is evaporated and the residue distilled to give methyl-γ-chloroacetoacetate, b.p. 48°-50° C./0.8 mb.

後処理

  1. filtrationthe solids are filtered off
  2. customthe filtrate is evaporated
  3. distillationthe residue distilled

出典と根拠

ORDレコード
ord-f4d83ff76a0c47e19a5a0dcaca20dabd
出典データセット
uspto-grants-1984_09
特許番号
US04472589

反応ノート

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