化工社化工社 化学情報印刷レポート · 研究参考用
Trifluoroacetic acid → HDTrp-Leu-MetNH2 trifluoroacetate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Trifluoroacetic acid | HCID 6422 | — |
| 反応物 | BocDTrp-Leu-MetNH2 | HCID 131713756 | — |
| 溶媒 | Ethyl methyl sulfide | HCID 12230 | — |
| 溶媒 | 1,1-Ethanedithiol | HCID 33645 | — |
| 生成物 | HDTrp-Leu-MetNH2 trifluoroacetate | HCID 131713755 | 23% |
反応手順
Condensation of BocDTrpOPFP (8.60 g.) and HLeu-MetNH2 hydrochloride salt (Example 1, 5.44 g.) by the activated ester method gave BocDTrp-Leu-MetNH2 in 67% yield. De-t-butoxycarbonylation of BocDTrp-Leu-MetNH2 (6.69 g.) using trifluoroacetic acid in methyl ethyl sulfide and ethanedithiol gave HDTrp-Leu-MetNH2 trifluoroacetate salt in 23% yield.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04472305 |
| 出典データセット | uspto-grants-1984_09 |
| ORD ID | ord-61fdc32b2888445d9cfb55f8896090df |
| 出典メモ | uspto-grants-1984_09 |