Ammonia → 6-(Aminomethyl)pyrimidine-2,4(1H,3H)-dione
反応式
Cl[CH2:2][C:3]1[NH:8][C:7](=[O:9])[NH:6][C:5](=[O:10])[CH:4]=1.[NH3:11]>C(OCC)(=O)C>[NH2:11][CH2:2][C:3]1[NH:8][C:7](=[O:9])[NH:6][C:5](=[O:10])[CH:4]=1参加物
4
実験手順
A mixture of 100 g (0.623 mole) of 6-chloromethylpyrimidine-2,4-dione and 200 ml of anhydrous ammonia was allowed to react overnight in a sealed bomb at about 20° C. The solid residue was slurried in ethyl acetate, separated by filtration, and washed sequentially with water and methanol to provide 6-aminomethylpyrimidine-2,4-dione, m.p. 295°-297° C.
後処理
- customto react overnight in a sealed bomb at about 20° C
- customseparated by filtration
- washwashed sequentially with water and methanol
出典と根拠
- ORDレコード
- ord-579362fbdc4e4dc2bed4bbb1e3dcd3be
- 出典データセット
- uspto-grants-1984_09
- 特許番号
- US04473570
反応ノート
読み込み中…