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Methanol → 2,3-methylenedioxy-11-oxo-11H-pyrido[2,1-b]quinazoline-6-carboxylic acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Methanol | HCID 887 | — |
| 反応物 | 2-Chloronicotinic acid | HCID 76258 | — |
| 反応物 | Methyl 6-amino-1,3-benzodioxole-5-carboxylate | HCID 290838 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | 2,3-methylenedioxy-11-oxo-11H-pyrido[2,1-b]quinazoline-6-carboxylic acid | HCID 20316839 | — |
反応手順
A mixture of 2.00g (10.4 mmol) of methyl 2-amino-4,5-methylenedioxybenzoate, 1.67g (10.4 mmol) of 2-chloronicotinic acid and 50mg of KI was heated at 170° for 1 hour. The fusion or melt gradually solidified to an orange cake. The solid material was heated in boiling methanol (250 ml) and then filtered to yield 1.60g of crude product, mp. 273°-280° dec. The analytical sample was obtained by recrystallization from DMF, mp. 300°-304° dec.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04104389 |
| 出典データセット | uspto-grants-1978_08 |
| ORD ID | ord-6c4ebe5621724a688721fa60eaf7865f |
| 出典メモ | uspto-grants-1978_08 |