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1,1'-Carbonyldiimidazole → 1-(1,4-Benzodioxan-2-yl-acetyl)-4-ethoxy-4-phenylpiperidine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 1,1'-Carbonyldiimidazole | HCID 68263 | — |
| 反応物 | 2,3-Dihydro-1,4-benzodioxin-2-acetic acid | HCID 267534 | — |
| 反応物 | 4-Ethoxy-4-phenylpiperidinium chloride | HCID 417392 | — |
| 溶媒 | Tetrahydrofuran | HCID 8028 | — |
| 生成物 | 1-(1,4-Benzodioxan-2-yl-acetyl)-4-ethoxy-4-phenylpiperidine | HCID 21331994 | — |
反応手順
The starting material is prepared as follows: To the solution of 3.3 g of 1,4-benzodioxan-2-yl-acetic acid in 30 ml of tetrahydrofuran, 3.1 g of 1,1'-carbonyldiimidazole are added while stirring followed, after 30 minutes, by 3.5 g of 4-ethoxy-4-phenylpiperidine in 30 ml of tetrahydrofuran. The mixture is stirred for 18 hours at room temperature, evaporated and the residue taken up in ethyl acetate. The solution is washed with water, N hydrochloric acid and saturated aqueous sodium chloride, dried and evaporated, to yield the 1-(1,4-benzodioxan-2-yl-acetyl)-4-ethoxy-4-phenylpiperidine.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04104396 |
| 出典データセット | uspto-grants-1978_08 |
| ORD ID | ord-1df656d30f7a44eea3fd033da6994b9d |
| 出典メモ | uspto-grants-1978_08 |