4-(2-Chloro-2-cyanoethyl)benzoic acid → 4-(2-Cyanoethyl)benzoic acid

HRID 2419195ノート

反応式

HRID 2419195 の反応式
Cl[CH:2]([C:13]#[N:14])[CH2:3][C:4]1[CH:12]=[CH:11][C:7]([C:8]([OH:10])=[O:9])=[CH:6][CH:5]=1>[Zn].C(O)(=O)C>[C:13]([CH2:2][CH2:3][C:4]1[CH:12]=[CH:11][C:7]([C:8]([OH:10])=[O:9])=[CH:6][CH:5]=1)#[N:14]

参加物

4

反応物 1

HCID 508886404-(2-Chloro-2-cyanoethyl)benzoic acid

生成物 1

HCID 198791964-(2-Cyanoethyl)benzoic acid

試薬・触媒・溶媒 2

HCID 23994Zinc触媒HCID 176Acetic Acid溶媒

実験手順

100 parts of zinc powder are gradually added to a solution of 209.5 parts of 4-(2-chloro-2-cyanoethyl) benzoic acid in 500 parts of glacial acetic acid. The temperature rises quickly up to reflux and is maintained for approximately one hour. The solution is filtered when hot so as to eliminate the insoluble matter, then the filtrate is diluted with 1,000 parts of water and the precipitate formed is isolated. Thus 122 parts of 4-(2-cyanoethyl) benzoic acid are obtained. M.P.: 182° C.

後処理

  1. temperatureto reflux
  2. temperatureis maintained for approximately one hour
  3. filtrationThe solution is filtered when hot so as
  4. additionthe filtrate is diluted with 1,000 parts of water
  5. customthe precipitate formed
  6. customis isolated

出典と根拠

ORDレコード
ord-6831b6236dcd41e4aa97d6b34ca2c166
出典データセット
uspto-grants-1978_08
特許番号
US04105653

反応ノート

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