4'-Hydroxyacetophenone → HCID 20315614、化合物

HRID 2419355ノート

反応式

HRID 2419355 の反応式
C(=O)([O-])[O-].[K+].[K+].Br[CH2:8][C:9]([O:11][CH:12]([CH3:14])[CH3:13])=[O:10].[CH3:15][C:16]([C:18]1[CH:19]=[CH:20][C:21]([OH:24])=[CH:22][CH:23]=1)=[O:17]>CC(C)=O>[C:16]([C:18]1[CH:23]=[CH:22][C:21]([O:24][CH2:8][C:9]([O:11][CH:12]([CH3:14])[CH3:13])=[O:10])=[CH:20][CH:19]=1)(=[O:17])[CH3:15]

参加物

5

反応物 3

HCID 74694'-HydroxyacetophenoneHCID 11430Potassium CarbonateHCID 121593Isopropyl bromoacetate

生成物 1

HCID 20315614HCID 20315614、化合物

試薬・触媒・溶媒 1

HCID 180Acetone溶媒

実験手順

Potassium carbonate (17.0g.) was added to a solution of isopropyl bromoacetate (24.0g.) and 4-hydroxyacetophenone (17.7g.) in acetone (200ml.). The mixture was heated under reflux for 24 hours, cooled and filtered. The filtrate was evaporated to an oil which was dissolved in ether (150ml.). The solution was washed with sodium bicarbonate solution (2 × 30ml.), water (2 × 30ml.), dried and evaporated. The residual oil was distilled to give isopropyl 4-acetylphenoxyacetate, I.R. peaks at 1750 and 1670 cm-1.

後処理

  1. temperatureThe mixture was heated
  2. temperatureunder reflux for 24 hours
  3. temperaturecooled
  4. filtrationfiltered
  5. customThe filtrate was evaporated to an oil which
  6. dissolutionwas dissolved in ether (150ml.)
  7. washThe solution was washed with sodium bicarbonate solution (2 × 30ml.), water (2 × 30ml.)
  8. customdried
  9. customevaporated
  10. distillationThe residual oil was distilled

出典と根拠

ORDレコード
ord-4623b85c58ac4ffcb1ff0d3dc1f645c1
出典データセット
uspto-grants-1978_08
特許番号
US04105790

反応ノート

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