Boron trifluoride etherate → 3-(Tetrahydropyran-2-ylthio)-2-methylpropanoic acid
反応式
[SH:1][CH2:2][CH:3]([CH3:7])[C:4]([OH:6])=[O:5].[O:8]1[CH:13]=[CH:12][CH2:11][CH2:10][CH2:9]1.B(F)(F)F.CCOCC.C(=O)([O-])[O-].[K+].[K+]>C1C=CC=CC=1>[O:8]1[CH2:13][CH2:12][CH2:11][CH2:10][CH:9]1[S:1][CH2:2][CH:3]([CH3:7])[C:4]([OH:6])=[O:5]参加物
6
実験手順
To a solution of 3-mercapto-2-methylpropanoic acid (2.4 g.) and freshly distillled 2,3-dihydro-4H-pyrane (1.9 g.) in benzene (60 ml.), boron trifluoride etherate (2.8 g.) is added. After two hours, potassium carbonate (4 g.) is added, the mixture is stirred and filtered. The filtrate is concentrated to dryness to yield 3-(tetrahydropyran-2-ylthio)-2-methylpropanoic acid.
後処理
- filtrationfiltered
- concentrationThe filtrate is concentrated to dryness
出典と根拠
- ORDレコード
- ord-cf192b03bd9847c788456f18f38cb8e9
- 出典データセット
- uspto-grants-1978_08
- 特許番号
- US04105776
反応ノート
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