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Methyl Nicotinate → Nicotinic Acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Methyl Nicotinate | HCID 7151 | — |
| 反応物 | 1,4-Dioxane | HCID 31275 | — |
| 反応物 | 3-Amino-4-nitrobenzotrifluoride | HCID 223100 | — |
| 反応物 | 2-Amino-4-nitrobenzotrifluoride | HCID 2737719 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | Nicotinic Acid | HCID 938 | 46.4% |
反応手順
Add 20 ml of dioxan and 10 g of 2-trifluoromethyl-5-nitroaniline or 2-nitro-5-trifluoromethyl-aniline to 12 g of nicotinic acid methyl ester. Reflux for 60 hours; then pour the reaction mass into water. Filter the resulting solid and recrystallize several times from ethanol. 5 g of (I) or (III) are thus obtained with the same melting-point values as the products of Examples 1 and 3.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04107316 |
| 出典データセット | uspto-grants-1978_08 |
| ORD ID | ord-fa18031f90554cfdad678aafad4662a9 |
| 出典メモ | uspto-grants-1978_08 |