Hydrochloric Acid → 1-(2,6-Difluorophenyl)methanamine--hydrogen chloride (1/1)
反応式
[F:1][C:2]1[CH:9]=[CH:8][CH:7]=[C:6]([F:10])[C:3]=1[C:4]#[N:5].[ClH:11].[H][H]>O.C(O)C>[ClH:11].[F:1][C:2]1[CH:9]=[CH:8][CH:7]=[C:6]([F:10])[C:3]=1[CH2:4][NH2:5]参加物
6
実験手順
A mixture of 5.00 g. of 2,6-difluorobenzonitrile and 1.0 g. of 50% water-wet 5% palladium on carbon catalyst in 100 ml. of concentrated HCl and 100 ml. of absolute ethanol is shaken at room temperature under 20 lbs. pressure of hydrogen for 48 hours. The mixture is filtered and the filtrate is diluted with 500 ml. of diethyl ether and allowed to stand. Filtration gives the desired product as colorless crystals, m.p. 197°-200° C.
後処理
- additionA mixture of 5.00 g
- filtrationThe mixture is filtered
- additionthe filtrate is diluted with 500 ml
- filtrationFiltration
出典と根拠
- ORDレコード
- ord-86ecba610cd448b1be5df9d91fb236ae
- 出典データセット
- uspto-grants-1978_08
- 特許番号
- US04107326
反応ノート
読み込み中…