化工社化工社 化学情報印刷レポート · 研究参考用
Triethylamine → Ethyl 2-diazo-3-(2,6-difluorophenyl)-3-oxopropanoate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Triethylamine | HCID 8471 | — |
| 反応物 | 4-Acetamidobenzenesulfonyl azide | HCID 5129185 | — |
| 反応物 | Ethyl 3-(2,6-difluorophenyl)-3-oxopropanoate | HCID 13550002 | — |
| 溶媒 | Acetonitrile | HCID 6342 | — |
| 生成物 | Ethyl 2-diazo-3-(2,6-difluorophenyl)-3-oxopropanoate | HCID 86681842 | — |
反応手順
Ethyl 3-(2,6-difluorophenyl)-3-oxopropanoate (12.3 g, 53.8 mmol) and triethylamine (22.5 mL, 0.161 mol, 3.0 equiv) were dissolved in acetonitrile (160 mL) and treated with 4-acetamidobenzenesulfonyl azide. The mixture was stirred for 18 hours at ambient temperature, concentrated in vacuo and the residue was purified by silica gel chromatography (eluting with chloroform), providing the titled compound.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08653079B2 |
| 出典データセット | uspto-grants-2014_02 |
| ORD ID | ord-e0f28b7b3da446fe96e04a73dd325fa2 |
| 出典メモ | uspto-grants-2014_02 |