Ethanol → 2-(4-Chlorobenzyloxy)-3,3,3-trifluoro-2-trifluoromethylpropionamide

反応式

[Cl:1][C:2]1[CH:20]=[CH:19][C:5]([CH2:6][O:7][C:8]([C:15]([F:18])([F:17])[F:16])([C:11]([F:14])([F:13])[F:12])[C:9]#[N:10])=[CH:4][CH:3]=1.[OH-].[K+].C([OH:25])C>O>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([CH2:6][O:7][C:8]([C:11]([F:12])([F:13])[F:14])([C:15]([F:16])([F:17])[F:18])[C:9]([NH2:10])=[O:25])=[CH:19][CH:20]=1

参加物

実験手順

A mixture of 2-(4-chlorobenzyloxy)-3,3,3-trifluoro-2-trifluoromethylpropionitrile (20 g.), potassium hydroxide (25 g.), ethanol (250 ml.) and water (250 ml.) is heated under reflux for 15 minutes. Most of the ethanol is evaporated in vacuo, and the residue is cooled until the precipitated oil solidifies. The solid is filtered off, and is recrystallised from a mixture of ether and light petroleum (b.p. 40°-60° C.) (charcoal) to give 2-(4-chlorobenzyloxy)-3,3,3-trifluoro-2-trifluoromethylpropionamide, m.p. 94°-95° C. (13.9 g.).