Benzene → 3,3,3-Trifluoro-1-phenylpropan-1-one

反応式

CN(C)C(=[O:14])N(C1C=CC(F)=C(Cl)C=1)N.[F:16][C:17]([F:28])([F:27])[C:18]1C=C(C(=O)C)C=C[CH:23]=1.[CH:29]1[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=1>>[F:16][C:17]([F:28])([F:27])[CH2:18][C:23]([C:29]1[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=1)=[O:14]

参加物

反応物 3

HCID 241Benzene

HCID 676823'-(Trifluoromethyl)acetophenone

HCID 127899361-(3-Chloro-4-fluorophenyl)-N,N-dimethylhydrazine-1-carboxamide

生成物 1

HCID 98341553,3,3-Trifluoro-1-phenylpropan-1-one

実験手順

To a solution of 10 grams of 4,4-dimethyl-2-(3-chloro-4-fluorophenyl)semicarbazide in 200 milliliters of benzene was added 8.1 grams of m-trifluoromethylacetophenone. This mixture was stirred and heated at reflux for 18 hours. The solvent was removed and the residue purified by silica chromatography to give 13 grams (75.1 yield) of 2-trifluoromethylacetophenone, 4,4-dimethyl-2-(3-chloro-4-fluorophenyl) semicarbazone as an amber syrup.