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Hydrochloric Acid → 2-Carboxy-3-methyl-5,6-dihydro-1,4-dithiin
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | Potassium Hydroxide | HCID 14797 | — |
| 反応物 | Ethyl 3-methyl-5,6-dihydro-1,4-dithiine-2-carboxylate | HCID 12368330 | — |
| 溶媒 | Methanol | HCID 887 | — |
| 生成物 | 2-Carboxy-3-methyl-5,6-dihydro-1,4-dithiin | HCID 600502 | — |
反応手順
3-Ethoxycarbonyl-2-methyl-5,6-dihydro-1,4-dithiin (10.0 g.) is heated at reflux for eight hours in a solution of potassium hydroxide (85%; 3.60 g.) in methanol (40 ml.). The cool solution is acidified wth 10% aqueous hydrochloric acid and the precipitate is removed by filtration and dried (8.1 g.). The crude product is recrystallized from ethanol to afford 2-carboxy-3-methyl-5,6-dihydro-1,4-dithiin, m.p. 179°-180° C., dec.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04109006 |
| 出典データセット | uspto-grants-1978_08 |
| ORD ID | ord-70e4d169155a4e7c915561bf3de09c9b |
| 出典メモ | uspto-grants-1978_08 |