Hydrochloric Acid → Indeloxazine Hydrochloride

HRID 2420182ノート

反応式

HRID 2420182 の反応式
[ClH:1].C1(C(C2C=CC=CC=2)(C2C=CC=CC=2)[N:9]2[CH2:14][CH2:13][O:12][CH:11]([CH:15]([O:17][C:18]3[CH:26]=[CH:25][CH:24]=[C:23]4[C:19]=3[CH2:20][CH2:21][CH2:22]4)O)[CH2:10]2)C=CC=CC=1>C(O)C>[ClH:1].[CH2:20]1[C:19]2[C:23](=[CH:24][CH:25]=[CH:26][C:18]=2[O:17][CH2:15][CH:11]2[O:12][CH2:13][CH2:14][NH:9][CH2:10]2)[CH:22]=[CH:21]1

参加物

4

反応物 2

HCID 313Hydrochloric AcidHCID 20313214HCID 20313214、化合物

生成物 1

HCID 47517Indeloxazine Hydrochloride

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

In 500 ml. of ethanolic hydrochloric acid (350 ml. of 0.5 N hydrochloric acid and 150 ml. of ethanol) was dissolved 5.0 g. of 4-triphenylmethyl-2-(1-hydroxy-4-indanyloxymethyl)-morpholine and the solution was refluxed 17 hours. After cooling the reaction mixture, ethanol was distilled away under reduced pressure until the whole volume of the reaction mixture became about 350 ml. Sodium chloride was added to the reaction mixture to cause salting out and the mixture was extracted three times each time with 200 ml. of chloroform. The chloroform extracts were combined, dried over anhydrous magnesium sulfate, and then the solvent was distilled away under reduced pressure. Then, by adding acetone to the syrupy residue formed, 2.0 g. of 2-(7-indenyloxymethyl)morpholine hydrochloride was obtained as a precipitate.

後処理

  1. distillationwas distilled away under reduced pressure until the whole volume of the reaction mixture
  2. additionSodium chloride was added to the reaction mixture
  3. extractionwas extracted three times each time with 200 ml
  4. dry with materialdried over anhydrous magnesium sulfate
  5. distillationthe solvent was distilled away under reduced pressure
  6. additionThen, by adding acetone to the syrupy residue
  7. customformed

出典と根拠

ORDレコード
ord-37463e11daf2448fa551417aa6193d90
出典データセット
uspto-grants-1978_08
特許番号
US04109088

反応ノート

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