Hydrochloric Acid → 2-{1-[1-(4-Chloro-phenyl)-cyclobutyl]-3,4-dihydro-isoquinolin-7-yloxy}-1-piperazin-1-yl-ethanone

HRID 242053ノート

反応式

HRID 242053 の反応式
C(OC([N:8]1[CH2:13][CH2:12][N:11]([C:14](=[O:38])[CH2:15][O:16][C:17]2[CH:26]=[C:25]3[C:20]([CH2:21][CH2:22][N:23]=[C:24]3[C:27]3([C:31]4[CH:36]=[CH:35][C:34]([Cl:37])=[CH:33][CH:32]=4)[CH2:30][CH2:29][CH2:28]3)=[CH:19][CH:18]=2)[CH2:10][CH2:9]1)=O)(C)(C)C.Cl.CC(O)C>ClCCl>[Cl:37][C:34]1[CH:35]=[CH:36][C:31]([C:27]2([C:24]3[C:25]4[C:20](=[CH:19][CH:18]=[C:17]([O:16][CH2:15][C:14]([N:11]5[CH2:12][CH2:13][NH:8][CH2:9][CH2:10]5)=[O:38])[CH:26]=4)[CH2:21][CH2:22][N:23]=3)[CH2:30][CH2:29][CH2:28]2)=[CH:32][CH:33]=1

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 3776IsopropanolHCID 582463044-(2-{1-[1-(4-Chloro-phenyl)-cyclobutyl]-3,4-dihydro-isoquinolin-7-yloxy}-acetyl)-piperazine-1-carboxylic acid tert-butyl ester

生成物 1

HCID 582463622-{1-[1-(4-Chloro-phenyl)-cyclobutyl]-3,4-dihydro-isoquinolin-7-yloxy}-1-piperazin-1-yl-ethanone

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

4-(2-{1-[1-(4-Chloro-phenyl)-cyclobutyl]-3,4-dihydro-isoquinolin-7-yloxy}-acetyl)-piperazine-1-carboxylic acid tert-butyl ester (690 mg, 1.28 mmol) was dissolved in dichloro-methane. A 5 M solution of HCl in 2-propanol (5 mol) was added and the mixture was stirred for 14 h at RT. The solvent was removed and the residue (230 mg) was used in the next step without further purification.

後処理

  1. customThe solvent was removed
  2. customthe residue (230 mg) was used in the next step without further purification

出典と根拠

ORDレコード
ord-e8f8b1c6103e4e24afb9c927cd8f3e5d
出典データセット
uspto-grants-2014_02
特許番号
US08653100B2

反応ノート

読み込み中…