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Diethylaminopropyl chloride, hydrochloride → 3-(3-Diethylaminopropyl)-5-(indol-3-ylmethyl)hydantoin
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Diethylaminopropyl chloride, hydrochloride | HCID 145749 | — |
| 反応物 | 5-(1h-Indol-3-ylmethyl)imidazolidine-2,4-dione | HCID 242867 | — |
| 反応物 | Sodium ethoxide | HCID 2723922 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 生成物 | 3-(3-Diethylaminopropyl)-5-(indol-3-ylmethyl)hydantoin | HCID 20312119 | — |
反応手順
A mixture of 5-(indol-3-ylmethyl)hydantoin (10 g, 0.04 mole), 3-chloro-N,N-diethylpropylamine hydrochloride (8.2 g, 0.04 mole), NaOC2H5 (0.08 mole) and 500 ml of anhydrous C2H5OH was heated to reflux with stirring for 20 hours. The mixture was filtered and concentrated to dryness. The concentrate was dissolved in CHCl3, filtered and concentrated. The concentrate was crystallized and recrystallized from benzene-petroleum ether. The solid was again recrystallized from xylene and the solvated solid was dried in vacuum, yield 2.5 g, mp 90°.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04110536 |
| 出典データセット | uspto-grants-1978_08 |
| ORD ID | ord-9fac1453dee7497da7051b9ae27155c3 |
| 出典メモ | uspto-grants-1978_08 |