1-Acetamido-3-(4'-fluoro-4-biphenylyl)-butane → 3-(4'-Fluoro-4-biphenylyl)butylamine
反応式
C([NH:4][CH2:5][CH2:6][CH:7]([C:9]1[CH:14]=[CH:13][C:12]([C:15]2[CH:20]=[CH:19][C:18]([F:21])=[CH:17][CH:16]=2)=[CH:11][CH:10]=1)[CH3:8])(=O)C>[OH-].[K+]>[F:21][C:18]1[CH:17]=[CH:16][C:15]([C:12]2[CH:13]=[CH:14][C:9]([CH:7]([CH3:8])[CH2:6][CH2:5][NH2:4])=[CH:10][CH:11]=2)=[CH:20][CH:19]=1参加物
3
実験手順
A solution of 28.5 g of 1-acetamido-3-(4'-fluoro-4-biphenylyl)-butane in 800 ml of 10% methanolic KOH solution is boiled for 48 hours. The solution is concentrated and worked up using water and ether to give 3-(4'-fluoro-4-biphenylyl)-butylamine; hydrochloride, m.p. 222° - 224°.
後処理
- concentrationThe solution is concentrated
出典と根拠
- ORDレコード
- ord-a471968d826c439f961a6074a8a2cde7
- 出典データセット
- uspto-grants-1978_08
- 特許番号
- US04110447
反応ノート
読み込み中…