関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | p-Toluenesulfonic acid | HCID 6101 | — |
| 反応物 | Acrylamide | HCID 6579 | — |
| 反応物 | Ethyl 4,4,5,5,5-Pentafluoro-3-oxovalerate | HCID 522203 | — |
| 溶媒 | Chlorobenzene | HCID 7964 | — |
| 生成物 | Ethyl 6-oxo-2-(pentafluoroethyl)-1,4,5,6-tetrahydropyridine-3-carboxylate | HCID 86611248 | 4.2% |
反応手順
A suspension of acrylamide (4.11 g), ethyl 4,4,5,5,5-pentafluoro-3-oxopentanoate (16.5 g) and p-toluenesulphonic acid (0.120 g) in chlorobenzene (40 mL) was sonicated for 30 minutes then heated by microwave irradiation (150 W, 120° C.) for 3 h. The reaction mixture was concentrated in vacuo and subjected to flash column chromatography (eluent 1:3 ethyl acetate/isohexane) to yield a colourless solid (0.697 g).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US07956070B2 |
|---|
| 出典データセット | uspto-grants-2011_06 |
|---|
| ORD ID | ord-66b8a55bacc44fc0b2643845168c18ad |
|---|
| 出典メモ | uspto-grants-2011_06 |
|---|
