Triethylamine → 1-Isopropylpyrrolidin-3-yl methanesulphonate
反応式
[CH:1]([N:4]1[CH2:8][CH2:7][CH:6]([OH:9])[CH2:5]1)([CH3:3])[CH3:2].C(N(CC)CC)C.[CH3:17][S:18](Cl)(=[O:20])=[O:19]>C1(C)C=CC=CC=1>[CH3:17][S:18]([O:9][CH:6]1[CH2:7][CH2:8][N:4]([CH:1]([CH3:3])[CH3:2])[CH2:5]1)(=[O:20])=[O:19]参加物
5
実験手順
A solution of 1-isopropylpyrrolidin-3-ol (2.0 ml) and triethylamine (2.5 ml) in toluene (25 ml) was cooled to 0° C. and methanesulphonyl chloride (1.4 ml) was added dropwise with stirring. The mixture was allowed to warm to ambient temperature and stirred for a further 2 h. The reaction was filtered and the filtrate evaporated to an oil which was used immediately.
後処理
- stirringstirred for a further 2 h
- filtrationThe reaction was filtered
- customthe filtrate evaporated to an oil which
出典と根拠
- ORDレコード
- ord-11369f871fa84c84a824fdd717950a0c
- 出典データセット
- uspto-grants-2011_06
- 特許番号
- US07956084B2
反応ノート
読み込み中…