4-Bromophenacyl bromide → 1-(4-Bromophenyl)-2-morpholinoethanone

HRID 2421394ノート

反応式

HRID 2421394 の反応式
[NH:1]1[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1.Br[CH2:8][C:9]([C:11]1[CH:16]=[CH:15][C:14]([Br:17])=[CH:13][CH:12]=1)=[O:10]>C1(C)C=CC=CC=1>[Br:17][C:14]1[CH:15]=[CH:16][C:11]([C:9](=[O:10])[CH2:8][N:1]2[CH2:6][CH2:5][O:4][CH2:3][CH2:2]2)=[CH:12][CH:13]=1

参加物

4

反応物 2

HCID 74544-Bromophenacyl bromideHCID 8083Morpholine

生成物 1

HCID 4108821-(4-Bromophenyl)-2-morpholinoethanone収率 101.3%

試薬・触媒・溶媒 1

HCID 1140Toluene溶媒2 回

実験手順

Morpholine (4.35 g) in dry toluene (8 ml) was stirred during the addition of aliquots of 2-bromo-1-(4-bromophenyl)ethanone (6.95 g) in dry toluene (70 ml). The resulting precipitate was removed by filtration and the filtrate evaporated to give the product (J. Amer. Chem. Soc., 1940, 62, 2882) as a pale yellow solid (7.2 g).

後処理

  1. customThe resulting precipitate was removed by filtration
  2. customthe filtrate evaporated

出典と根拠

ORDレコード
ord-b40b4806bb32466aa8de9b505667e52b
出典データセット
uspto-grants-2011_06
特許番号
US07956084B2

反応ノート

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