4-Fluoroaniline → {2-[(4-Fluorophenyl)amino]-6-methylpyrimidin-4-yl}methanol

HRID 242148ノート

反応式

HRID 242148 の反応式
Cl[C:2]1[N:7]=[C:6]([CH2:8][OH:9])[CH:5]=[C:4]([CH3:10])[N:3]=1.[F:11][C:12]1[CH:18]=[CH:17][C:15]([NH2:16])=[CH:14][CH:13]=1>C(OCC)C>[F:11][C:12]1[CH:18]=[CH:17][C:15]([NH:16][C:2]2[N:7]=[C:6]([CH2:8][OH:9])[CH:5]=[C:4]([CH3:10])[N:3]=2)=[CH:14][CH:13]=1

参加物

4

反応物 2

HCID 97314-FluoroanilineHCID 59462115(2-Chloro-6-methylpyrimidin-4-yl)methanol

生成物 1

HCID 59278633{2-[(4-Fluorophenyl)amino]-6-methylpyrimidin-4-yl}methanol

試薬・触媒・溶媒 1

HCID 3283Diethyl Ether溶媒

実験手順

50 mg (0.32 mmol) of the compound from example 5A and 350 mg (3.15 mmol) of 4-fluoroaniline are stirred together at 160° C. for 2 h. The reaction mixture is then poured into 10 ml of diethyl ether. The precipitate is filtered off and discarded and the filtrate is then purified chromatographically on silica gel 60 (mobile phase: gradient dichloromethane→dichloromethane/ethanol 50:1).

後処理

  1. filtrationThe precipitate is filtered off
  2. customthe filtrate is then purified chromatographically on silica gel 60 (mobile phase: gradient dichloromethane→dichloromethane/ethanol 50:1)

出典と根拠

ORDレコード
ord-23d0182987f647d7afe91c7ff6225499
出典データセット
uspto-grants-2014_02
特許番号
US08653109B2

反応ノート

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