(S)-4-fluoromethyl-dihydro-furan-2-one → HCID 66680203、化合物

HRID 2421514ノート

反応式

HRID 2421514 の反応式
FC[C@@H]1COC(=O)C1.N[C:10]1[CH:11]=[CH:12][CH2:13][N:14]2[CH:23]=[CH:22][C:21]3[C:16](=[CH:17][CH:18]=[CH:19][CH:20]=3)[C:15]=12>>[CH:10]1[CH:11]=[CH:12][CH2:13][N:14]2[CH:23]=[CH:22][C:21]3[C:16](=[CH:17][CH:18]=[CH:19][CH:20]=3)[C:15]=12

参加物

3

反応物 2

HCID 11990659(S)-4-fluoromethyl-dihydro-furan-2-oneHCID 66681322HCID 66681322、化合物

生成物 1

HCID 66680203HCID 66680203、化合物

実験手順

According to still another embodiment (Scheme 3) the (S)-4-fluoromethyl-dihydro-furan-2-one is directly coupled with the amino-pyrido[2,1-a]isoquinoline derivative (VIII) to form the hydroxymethyl derivative of the pyrido[2,1-a]isoquinoline (XI), which is subsequently cyclisized to the fluoromethyl-pyrrolidin-2-one derivative (IX). The latter can be deprotected to yield the desired pyrido[2,1-a]isoquinoline derivative (II).

出典と根拠

ORDレコード
ord-db8f03b34ab347e9abe9a2362d31e43d
出典データセット
uspto-grants-2011_06
特許番号
US07956201B2

反応ノート

読み込み中…