Propylamine → 4-Phenethyl-N-propyl-benzamide

反応式

[CH2:1]([C:9]1[CH:17]=[CH:16][C:12]([C:13]([OH:15])=O)=[CH:11][CH:10]=1)[CH2:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1.[CH2:18]([NH2:21])[CH2:19][CH3:20]>>[CH2:1]([C:9]1[CH:10]=[CH:11][C:12]([C:13]([NH:21][CH2:18][CH2:19][CH3:20])=[O:15])=[CH:16][CH:17]=1)[CH2:2][C:3]1[CH:4]=[CH:5][CH:6]=[CH:7][CH:8]=1

参加物

反応物 2

HCID 7852Propylamine

HCID 104894314-(2-Phenylethyl)benzoic acid

生成物 1

HCID 672142994-Phenethyl-N-propyl-benzamide

実験手順

Using preparation method 1, 76C (226 mg, 1 mmol) was reacted with n-propylamine (90 μL, 65 mg, 1.1 mmol). No purification was necessary. White crystals were obtained (103 mg, 39%). NMR 1H (ppm, CDCl3): 7.65 (d, J3=8.1 Hz, 2H), 7.28-7.12 (m, 7H), 6.05 (br. s, 1H), 3.44-3.38 (m, 2H), 3.01-2.92 (m, 4H), 1.63 (sext., J3=7.3 Hz, 2H), 0.98 (t, J3=7.4 Hz, 3H).

後処理

customNo purification
customWhite crystals were obtained (103 mg, 39%)

出典と根拠

ORDレコード: ord-afa9f944d23a429c9dfefbefee7ef819
出典データセット: uspto-grants-2011_06
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US07956216B2

反応ノート

読み込み中…

参加物