Water → 4-phenyl-N-propyl-1,3-thiazol-2-amine

HRID 2422236ノート

反応式

HRID 2422236 の反応式
Cl[CH2:2][C:3]([C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1)=O.[CH2:11]([NH:14][C:15]([NH2:17])=[S:16])[CH2:12][CH3:13].C([O-])(=O)C.[Na+].O>C(O)C>[C:5]1([C:3]2[N:17]=[C:15]([NH:14][CH2:11][CH2:12][CH3:13])[S:16][CH:2]=2)[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1

参加物

6

反応物 4

HCID 962WaterHCID 107572-ChloroacetophenoneHCID 517045Sodium AcetateHCID 1615208Propyl-2-thiourea

生成物 1

HCID 230827804-phenyl-N-propyl-1,3-thiazol-2-amine収率 92%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

To a solution of 2-chloroacetophenone (4.45 g, 28.8 mmol) and N-propylthiourea (3.40 g, 28.8 mmol) in ethanol (50 mL) was added sodium acetate (3.07 g, 37.4 mmol), and the mixture was heated under reflux for 1.5 hrs. Water was added to the reaction mixture, and crystals were collected by filtration. The obtained crude crystals were recrystallized from diethyl ether-hexane to give the title compound (5.64 g, 92%) as colorless crystals.

後処理

  1. temperaturethe mixture was heated
  2. temperatureunder reflux for 1.5 hrs
  3. filtrationwere collected by filtration
  4. customThe obtained crude crystals
  5. customwere recrystallized from diethyl ether-hexane

出典と根拠

ORDレコード
ord-1309f79e1cdd4cc4ba387db37e1eb03d
出典データセット
uspto-grants-2011_06
特許番号
US07960369B2

反応ノート

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