Morpholine → 4-(6-Chloropyrimidin-4-yl)morpholine

HRID 242246

反応式

HRID 242246 の反応式
Cl[C:2]1[CH:7]=[C:6]([Cl:8])[N:5]=[CH:4][N:3]=1.[NH:9]1[CH2:14][CH2:13][O:12][CH2:11][CH2:10]1>O>[Cl:8][C:6]1[N:5]=[CH:4][N:3]=[C:2]([N:9]2[CH2:14][CH2:13][O:12][CH2:11][CH2:10]2)[CH:7]=1

参加物

4

反応物 2

HCID 8083MorpholineHCID 709434,6-Dichloropyrimidine

生成物 1

HCID 7960704-(6-Chloropyrimidin-4-yl)morpholine

試薬・触媒・溶媒 1

HCID 962Water溶媒

反応条件

温度
90 °C

実験手順

45.0 g (302.1 mmol) 4,6-dichloropyrimidine are initially introduced into 450 ml water. 26.3 g (302.1 mmol) morpholine are added and the mixture is stirred at 90° C. for 16 h. Thereafter, it is cooled to 0° C. and the precipitate formed is filtered off. The precipitate is washed once with 50 ml water and dried in air.

後処理

  1. temperatureThereafter, it is cooled to 0° C.
  2. customthe precipitate formed
  3. filtrationis filtered off
  4. washThe precipitate is washed once with 50 ml water
  5. customdried in air

出典と根拠

ORDレコード
ord-a91756505a5e41009dac6d88413e4ae5
出典データセット
uspto-grants-2014_02
特許番号
US08653111B2

関連ノート

読み込み中…