Allyltributylstannane → 7-Allyl-4-phenylquinoline-2-carbonitrile

HRID 2422567ノート

反応式

HRID 2422567 の反応式
Cl[C:2]1[CH:11]=[C:10]2[C:5]([C:6]([C:14]3[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=3)=[CH:7][C:8]([C:12]#[N:13])=[N:9]2)=[CH:4][CH:3]=1.[CH2:20]([Sn](CCCC)(CCCC)CCCC)[CH:21]=[CH2:22]>O1CCOCC1>[CH2:22]([C:2]1[CH:11]=[C:10]2[C:5]([C:6]([C:14]3[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=3)=[CH:7][C:8]([C:12]#[N:13])=[N:9]2)=[CH:4][CH:3]=1)[CH:21]=[CH2:20]

参加物

4

反応物 2

HCID 90628AllyltributylstannaneHCID 597749247-Chloro-4-phenylquinoline-2-carbonitrile

生成物 1

HCID 597748917-Allyl-4-phenylquinoline-2-carbonitrile

試薬・触媒・溶媒 1

HCID 312751,4-Dioxane溶媒

実験手順

To a solution of 7-chloro-4-phenylquinoline-2-carbonitrile (3.3 g, 12.5 mmol) in dioxane (120 mL) was added tetrakistriphenylphosphine (3.6 g, 3.1 mmol) and allyltributyltin (11.5 mL, 38 mmol). The mixture was refluxed for 10 h, concentrated and purified on silica gel (eluting with dichloromethane/hexanes, 3:1) to give the title compound. MS (+ESI): 271 (M+H)+.

後処理

  1. temperatureThe mixture was refluxed for 10 h
  2. concentrationconcentrated
  3. custompurified on silica gel (eluting with dichloromethane/hexanes, 3:1)

出典と根拠

ORDレコード
ord-6e62ec91f88b452bbfd6a719e9259830
出典データセット
uspto-grants-2011_06
特許番号
US07960409B2

反応ノート

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