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4-Aminobenzoic Acid → 3-Methyl-2-[4-(3-piperidin-1-ylpropoxy)phenyl]pyrido[2,3-d]-pyrimidin-4(3h)-one
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 4-Aminobenzoic Acid | HCID 978 | — |
| 反応物 | 4-(3-Piperidin-1-ylpropoxy)benzaldehyde | HCID 2766324 | — |
| 反応物 | 4-{3-[(3S)-3-methylpiperidin-1-yl]propoxy}benzaldehyde | HCID 7379340 | — |
| 反応物 | 4-(3-Pyrrolidin-1-ylpropoxy)benzaldehyde | HCID 11651573 | — |
| 反応物 | 4-[(1-Cyclopentylpiperidin-4-yl)oxy]-2-methoxybenzaldehyde | HCID 86084804 | — |
| 反応物 | 4-[(1-Cyclopentyl-4-piperidinyl)oxy]benzaldehyde | HCID 86624460 | — |
| 反応物 | 4-[(1-Cyclobutyl-4-piperidinyl)oxy]benzaldehyde | HCID 86624461 | — |
| 反応物 | 4-[(1-Cyclobutylpiperidin-4-yl)oxy]-2-methoxybenzaldehyde | HCID 86624462 | — |
| 反応物 | 6-[(1-Cyclobutylpiperidin-4-yl)oxy]nicotinaldehyde | HCID 86624463 | — |
| 反応物 | 2-[(1-Cyclobutylpiperidin-4-yl)oxy]pyrimidine-5-carbaldehyde | HCID 86624465 | — |
| 生成物 | 3-Methyl-2-[4-(3-piperidin-1-ylpropoxy)phenyl]pyrido[2,3-d]-pyrimidin-4(3h)-one | HCID 11639469 | — |
反応手順
Compounds of Examples 16 to 59 can be produced according to the method of Example 15 or a method similar to it or a combination of the method with an ordinary method, but starting from the corresponding aminobenzoic acid, amine and separately prepared aromatic aldehydes such as 4-(3-piperidin-1-ylpropoxy)benzaldehyde, 4-(3-pyrrolidin-1-ylpropoxy)benzaldehyde, 4-[(1-cyclopentyl-4-piperidinyl)oxy]benzaldehyde, 4-[(1-cyclobutyl-4-piperidinyl)oxy]benzaldehyde, 4-[(1-cyclopentylpiperidin-4-yl)oxy]-2-methoxybenzaldehyde, 4-[(1-cyclobutylpiperidin-4-yl)oxy]-2-methoxybenzaldehyde, 6-[(1-cyclobutylpiperidin-4-yl)oxy]nicotinaldehyde, 2-[(1-cyclobutylpiperidin-4-yl)oxy]pyrimidine-5-carbaldehyde, 4-{3-[(3S)-3-methylpiperidin-1-yl]propoxy}benzaldehyde.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07960394B2 |
| 出典データセット | uspto-grants-2011_06 |
| ORD ID | ord-4e79d52b8f524476a39c9c47a8fc7d55 |
| 出典メモ | uspto-grants-2011_06 |