Methylamine → 6-Chloro-2-{4-[(1-cyclobutylpiperidin-4-yl)oxy]phenyl}-3-methylpyrido[3,4-d]pyrimidin-4(3H)-one

HRID 2422602

反応式

HRID 2422602 の反応式
[NH2:1][C:2]1[C:7]([C:8]([OH:10])=O)=[CH:6][C:5]([Cl:11])=[N:4][CH:3]=1.[CH3:12][NH2:13].[CH:14]1([N:18]2[CH2:23][CH2:22][CH:21]([O:24][C:25]3[CH:32]=[CH:31][C:28]([CH:29]=O)=[CH:27][CH:26]=3)[CH2:20][CH2:19]2)[CH2:17][CH2:16][CH2:15]1>>[Cl:11][C:5]1[N:4]=[CH:3][C:2]2[N:1]=[C:29]([C:28]3[CH:31]=[CH:32][C:25]([O:24][CH:21]4[CH2:22][CH2:23][N:18]([CH:14]5[CH2:17][CH2:16][CH2:15]5)[CH2:19][CH2:20]4)=[CH:26][CH:27]=3)[N:13]([CH3:12])[C:8](=[O:10])[C:7]=2[CH:6]=1

参加物

4

反応物 3

HCID 6329MethylamineHCID 227367915-Amino-2-chloro-isonicotinic acidHCID 866244614-[(1-Cyclobutyl-4-piperidinyl)oxy]benzaldehyde

生成物 1

HCID 116690506-Chloro-2-{4-[(1-cyclobutylpiperidin-4-yl)oxy]phenyl}-3-methylpyrido[3,4-d]pyrimidin-4(3H)-one

実験手順

The entitled compound was obtained according to the method of Example 15 but starting from 5-amino-2-chloroisonicotinic acid, methylamine and 4-[(1-cyclobutyl-4-piperidinyl)oxy]benzaldehyde.

後処理

  1. customThe entitled compound was obtained

出典と根拠

ORDレコード
ord-77b6a38bb7ac45b68a218a833933341e
出典データセット
uspto-grants-2011_06
特許番号
US07960394B2

関連ノート

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