Methylamine → 2-{4-[(1-Cyclopentylpiperidin-4-yl)oxy]phenyl}-8-methoxy-3-methylpyrido[3,4-d]pyrimidin-4(3H)-one

HRID 2422606

反応式

HRID 2422606 の反応式
[NH2:1][C:2]1[C:10]([O:11][CH3:12])=[N:9][CH:8]=[CH:7][C:3]=1[C:4]([OH:6])=O.[CH3:13][NH2:14].[CH:15]1([N:20]2[CH2:25][CH2:24][CH:23]([O:26][C:27]3[CH:34]=[CH:33][C:30]([CH:31]=O)=[CH:29][CH:28]=3)[CH2:22][CH2:21]2)[CH2:19][CH2:18][CH2:17][CH2:16]1>>[CH:15]1([N:20]2[CH2:25][CH2:24][CH:23]([O:26][C:27]3[CH:34]=[CH:33][C:30]([C:31]4[N:14]([CH3:13])[C:4](=[O:6])[C:3]5[CH:7]=[CH:8][N:9]=[C:10]([O:11][CH3:12])[C:2]=5[N:1]=4)=[CH:29][CH:28]=3)[CH2:22][CH2:21]2)[CH2:19][CH2:18][CH2:17][CH2:16]1

参加物

4

反応物 3

HCID 6329MethylamineHCID 536346183-Amino-2-methoxyisonicotinic acidHCID 866244604-[(1-Cyclopentyl-4-piperidinyl)oxy]benzaldehyde

生成物 1

HCID 116549862-{4-[(1-Cyclopentylpiperidin-4-yl)oxy]phenyl}-8-methoxy-3-methylpyrido[3,4-d]pyrimidin-4(3H)-one

実験手順

The entitled compound was obtained according to the method of Example 15 but starting from 3-amino-2-methoxyisonicotinic acid, methylamine and 4-[(1-cyclopentyl-4-piperidinyl)oxy]benzaldehyde.

後処理

  1. customThe entitled compound was obtained

出典と根拠

ORDレコード
ord-4ddf59afa00642f1996cc2c657370fb5
出典データセット
uspto-grants-2011_06
特許番号
US07960394B2

関連ノート

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