Methylamine → 2-{4-[(1-Cyclobutylpiperidin-4-yl)oxy]phenyl}-6-methoxy-3-methylpyrido[3,4-d]pyrimidin-4(3H)-one

HRID 2422620

反応式

HRID 2422620 の反応式
[NH2:1][C:2]1[C:7]([C:8]([OH:10])=O)=[CH:6][C:5]([O:11][CH3:12])=[N:4][CH:3]=1.[CH3:13][NH2:14].[CH:15]1([N:19]2[CH2:24][CH2:23][CH:22]([O:25][C:26]3[CH:33]=[CH:32][C:29]([CH:30]=O)=[CH:28][CH:27]=3)[CH2:21][CH2:20]2)[CH2:18][CH2:17][CH2:16]1>>[CH:15]1([N:19]2[CH2:24][CH2:23][CH:22]([O:25][C:26]3[CH:33]=[CH:32][C:29]([C:30]4[N:14]([CH3:13])[C:8](=[O:10])[C:7]5[CH:6]=[C:5]([O:11][CH3:12])[N:4]=[CH:3][C:2]=5[N:1]=4)=[CH:28][CH:27]=3)[CH2:21][CH2:20]2)[CH2:18][CH2:17][CH2:16]1

参加物

4

反応物 3

HCID 6329MethylamineHCID 27625075-Amino-2-methoxypyridine-4-carboxylic acidHCID 866244614-[(1-Cyclobutyl-4-piperidinyl)oxy]benzaldehyde

生成物 1

HCID 116331432-{4-[(1-Cyclobutylpiperidin-4-yl)oxy]phenyl}-6-methoxy-3-methylpyrido[3,4-d]pyrimidin-4(3H)-one

実験手順

The entitled compound was obtained according to the method of Example 15 but starting from 5-amino-2-methoxyisonicotinic acid, methylamine and 4-[(1-cyclobutyl-4-piperidinyl)oxy]benzaldehyde. The resulting compound was recrystallized from ethyl acetate-heptane to give a colorless tabular crystal (m.p. 146.5-148.0° C.).

後処理

  1. customThe entitled compound was obtained
  2. customThe resulting compound was recrystallized from ethyl acetate-heptane

出典と根拠

ORDレコード
ord-7a99071d993e407396c0e607bcec47e9
出典データセット
uspto-grants-2011_06
特許番号
US07960394B2

関連ノート

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