Methylamine → 3-Methyl-2-(4-{3-[(3S)-3-methylpiperidin-1-yl]propoxy}phenyl)pyrido[3,2-d]pyrimidin-4(3H)-one

HRID 2422622

反応式

HRID 2422622 の反応式
[NH2:1][C:2]1[C:3]([C:8]([OH:10])=O)=[N:4][CH:5]=[CH:6][CH:7]=1.[CH3:11][NH2:12].[CH3:13][C@H:14]1[CH2:19][CH2:18][CH2:17][N:16]([CH2:20][CH2:21][CH2:22][O:23][C:24]2[CH:31]=[CH:30][C:27]([CH:28]=O)=[CH:26][CH:25]=2)[CH2:15]1>>[CH3:11][N:12]1[C:8](=[O:10])[C:3]2[N:4]=[CH:5][CH:6]=[CH:7][C:2]=2[N:1]=[C:28]1[C:27]1[CH:30]=[CH:31][C:24]([O:23][CH2:22][CH2:21][CH2:20][N:16]2[CH2:17][CH2:18][CH2:19][C@H:14]([CH3:13])[CH2:15]2)=[CH:25][CH:26]=1

参加物

4

反応物 3

HCID 6329MethylamineHCID 738363-Aminopicolinic acidHCID 73793404-{3-[(3S)-3-methylpiperidin-1-yl]propoxy}benzaldehyde

生成物 1

HCID 114948813-Methyl-2-(4-{3-[(3S)-3-methylpiperidin-1-yl]propoxy}phenyl)pyrido[3,2-d]pyrimidin-4(3H)-one

実験手順

The entitled compound was obtained according to the method of Example 15 but starting from 3-aminopyridin-2-carboxylic acid, methylamine and 4-{3-[(3S)-3-methylpiperidin-1-yl]propoxy}benzaldehyde. The resulting compound was recrystallized from diethyl ether-heptane to give a colorless acicular crystal (m.p. 83.5-88.5° C.).

後処理

  1. customThe entitled compound was obtained
  2. customThe resulting compound was recrystallized from diethyl ether-heptane

出典と根拠

ORDレコード
ord-26b370b5224e4669b1e0f2ab18ea402c
出典データセット
uspto-grants-2011_06
特許番号
US07960394B2

関連ノート

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