Boron tribromide → 4-(5-Amino-4-methylisothiazol-3-yl)phenol

HRID 2422703

反応式

HRID 2422703 の反応式
B(Br)(Br)Br.C[O:6][C:7]1[CH:12]=[CH:11][C:10]([C:13]2[C:17]([CH3:18])=[C:16]([NH2:19])[S:15][N:14]=2)=[CH:9][CH:8]=1>ClCCl>[NH2:19][C:16]1[S:15][N:14]=[C:13]([C:10]2[CH:11]=[CH:12][C:7]([OH:6])=[CH:8][CH:9]=2)[C:17]=1[CH3:18]

参加物

4

反応物 2

HCID 25134Boron tribromideHCID 534010803-(4-Methoxyphenyl)-4-methyl-1,2-thiazol-5-amine

生成物 1

HCID 1363552854-(5-Amino-4-methylisothiazol-3-yl)phenol収率 106.8%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

Add boron tribromide (0.227 g, 0.909 mmol) to a solution of 3-(4-methoxy-phenyl)-4-methylisothiazol-5-ylamine (0.100 g, 0.455 mmol) in dichloromethane (5 mL) at −20° C. Stir and allow to warm to room temperature. Stir 4 h and quench with 1 N HCl. Extract with EtOAc (2 times 50 mL). Dry (MgSO4) and evaporate. The product is used for the next step without further purification. Yield: 106.8% ES-MS: m/e 207.0 (m+1).

後処理

  1. stirringStir 4 h
  2. customquench with 1 N HCl
  3. extractionExtract with EtOAc (2 times 50 mL)
  4. dry with materialDry (MgSO4)
  5. customevaporate
  6. customThe product is used for the next step without further purification

出典と根拠

ORDレコード
ord-5d928e812cb34a688f8e133b726e02c0
出典データセット
uspto-grants-2011_06
特許番号
US07960419B2

関連ノート

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