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Iodine → (1-Fluorovinyl)methyldiphenylsilane
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Iodine | HCID 807 | — |
| 反応物 | Vinylidene fluoride | HCID 6369 | — |
| 反応物 | Chloro(methyl)diphenylsilane | HCID 67349 | — |
| 反応物 | Lithium | HCID 3028194 | — |
| 溶媒 | Tetrahydrofuran | HCID 8028 | — |
| 生成物 | (1-Fluorovinyl)methyldiphenylsilane | HCID 10922738 | — |
反応手順
To a solution of lithium wire (2.08 g, 300 mmol) in dry tetrahydrofuran (150 ml) was added methyldiphenylsilyl chloride (15.8 ml, 75 mmol) and a catalytic amount of iodine. The reaction mixture was sonicated for 40 min and then stirred overnight at room temperature. The reaction mixture was cooled to −78° C. and 1,1-difluoroethylene (approx. 225 mmol) was passed through the mixture for 30 min. The mixture was stirred at −78° C. for 2 h and then warmed to room temperature.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07960426B2 |
| 出典データセット | uspto-grants-2011_06 |
| ORD ID | ord-0cb1a0980144485798f1e36c6a256375 |
| 出典メモ | uspto-grants-2011_06 |