Ethyl 4-(3-naphthalen-2-yl-acryloylamino)benzoate → Methyl 4-(3-phenylacryloylamino)benzoate

HRID 2422937ノート

反応式

HRID 2422937 の反応式
[CH:1]1[C:10]2[C:5](=CC=CC=2)[CH:4]=[CH:3][C:2]=1[CH:11]=[CH:12][C:13]([NH:15][C:16]1[CH:26]=[CH:25][C:19]([C:20]([O:22][CH2:23]C)=[O:21])=[CH:18][CH:17]=1)=[O:14]>Cl>[C:2]1([CH:11]=[CH:12][C:13]([NH:15][C:16]2[CH:17]=[CH:18][C:19]([C:20]([O:22][CH3:23])=[O:21])=[CH:25][CH:26]=2)=[O:14])[CH:1]=[CH:10][CH:5]=[CH:4][CH:3]=1

参加物

3

反応物 1

HCID 67243223Ethyl 4-(3-naphthalen-2-yl-acryloylamino)benzoate

生成物 1

HCID 675852Methyl 4-(3-phenylacryloylamino)benzoate

試薬・触媒・溶媒 1

HCID 313Hydrochloric Acid溶媒

実験手順

This was obtained as a white solid from cinnamoyl chloride (1.1 g, 6.62 mmol) and ethyl 4-aminobenzoate (1.10 g, 6.62 mmol) in a similar manner as described for preparation of 42. The reaction mixture was stirred at room temperature overnight and the mixture was poured in HCl (aq, 2N, 20 ml). The product was extracted with DCM (2×20 ml), dried over Na2SO4 and the solvent removed under reduced pressure. The crude amide 41 was used in the next step without further purification.

後処理

  1. extractionThe product was extracted with DCM (2×20 ml)
  2. dry with materialdried over Na2SO4
  3. customthe solvent removed under reduced pressure
  4. customThe crude amide 41 was used in the next step without further purification

出典と根拠

ORDレコード
ord-4f825ae8d3534a5bba9a7c942e720f98
出典データセット
uspto-grants-2011_06
特許番号
US07960434B2

反応ノート

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