4-(2-Amino-2-methylpropoxy)-3-fluorobenzonitrile → 4-(2-Dimethylamino-2-methylpropoxy)-3-fluorobenzaldehyde

HRID 2423570ノート

反応式

HRID 2423570 の反応式
NC(C)(C)C[O:4]C1C=CC(C#N)=CC=1F.[CH3:16][N:17]([CH3:32])[C:18]([CH3:31])([CH3:30])[CH2:19][O:20][C:21]1[CH:28]=[CH:27][C:24]([C:25]#N)=[CH:23][C:22]=1[F:29]>>[CH3:16][N:17]([CH3:32])[C:18]([CH3:31])([CH3:30])[CH2:19][O:20][C:21]1[CH:28]=[CH:27][C:24]([CH:25]=[O:4])=[CH:23][C:22]=1[F:29]

参加物

3

反応物 2

HCID 230872344-(2-Amino-2-methylpropoxy)-3-fluorobenzonitrileHCID 230874174-(2-Dimethylamino-2-methylpropoxy)-3-fluorobenzonitrile

生成物 1

HCID 230871524-(2-Dimethylamino-2-methylpropoxy)-3-fluorobenzaldehyde

実験手順

Synthesized from 4-(2-amino-2-methylpropoxy)-3-fluorobenzonitrile according to an analogous synthetic method to Preparation Example 18, 4-(2-dimethylamino-2-methylpropoxy)-3-fluorobenzonitrile (1.4 g) was used according to an analogous synthetic method to Preparation Example 16 to provide the title compound (965 mg).

後処理

  1. customwas used according to an analogous synthetic method to Preparation Example 16

出典と根拠

ORDレコード
ord-7cc2337730eb4a5fae32ae28a2627444
出典データセット
uspto-grants-2011_06
特許番号
US07960412B2

反応ノート

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