4-Piperidinol, 1-methyl- → HCID 23087228、化合物

HRID 2423573ノート

反応式

HRID 2423573 の反応式
[OH:1]C1CCN(C)CC1.FC1C=C(C=CC=1F)C#N.[F:19][C:20]1[CH:21]=[C:22]([CH:25]=[CH:26][C:27]=1[O:28][CH:29]1[CH2:34][CH2:33][N:32]([CH3:35])[CH2:31][CH2:30]1)[C:23]#N>>[F:19][C:20]1[CH:21]=[C:22]([CH:25]=[CH:26][C:27]=1[O:28][CH:29]1[CH2:34][CH2:33][N:32]([CH3:35])[CH2:31][CH2:30]1)[CH:23]=[O:1]

参加物

4

反応物 3

HCID 660484-Piperidinol, 1-methyl-HCID 5872033,4-DifluorobenzonitrileHCID 230874123-Fluoro-4-(1-methylpiperidin-4-yloxy)benzonitrile

生成物 1

HCID 23087228HCID 23087228、化合物

実験手順

Synthesized from 4-hydroxy-1-methylpiperidine and 3,4-difluorobenzonitrile according to an analogous synthetic method to Preparation Example 15, 3-fluoro-4-(1-methylpiperidin-4-yloxy)benzonitrile (1.1 g) was used according to an analogous synthetic method to Preparation Example 16 to provide the title compound (1.1 g).

後処理

  1. customwas used according to an analogous synthetic method to Preparation Example 16

出典と根拠

ORDレコード
ord-7da41b010ebd47aab4379e8fc531c776
出典データセット
uspto-grants-2011_06
特許番号
US07960412B2

反応ノート

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