化工社化工社 化学情報印刷レポート · 研究参考用
L-Leucine, N-((1,1-dimethylethoxy)carbonyl)- → (S)-2-tert-Butoxycarbonylamino-3-phenyl propionic acid [2-acetyl-1-(2-trimethylsilylethoxymethyl)-1H-imidazol-4-yl]methylester
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | L-Leucine, N-((1,1-dimethylethoxy)carbonyl)- | HCID 83170 | — |
| 反応物 | 1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride | HCID 2723939 | — |
| 反応物 | 1-(4-hydroxymethyl-1-(2-trimethylsilylethoxymethyl)-1H-imidazol-2-yl)ethanone | HCID 71086972 | — |
| 触媒 | 4-(Dimethylamino)pyridine | HCID 14284 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | (S)-2-tert-Butoxycarbonylamino-3-phenyl propionic acid [2-acetyl-1-(2-trimethylsilylethoxymethyl)-1H-imidazol-4-yl]methylester | HCID 71105111 | — |
反応手順
The compound (2.00 g) obtained in (3) was dissolved in dichloromethane (10 mL), and Boc-Leu-OH (2.21 g), EDC.HCl (2.13 g), and DMAP (0.99 g) were added while stirring. After the stirring was continued for 1 day, the solvent was distilled off under reduced pressure. The resulting residue was purified by flash chromatography (ethyl acetate/chloroform=0%→25%) using silica gel column (product name: Hi-Flash Column 3 L, manufactured by Yamazen Corporation) to afford the title compound (3.20 g).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08653126B2 |
| 出典データセット | uspto-grants-2014_02 |
| ORD ID | ord-ee60c6e8bc1744969018dda8e777ca7c |
| 出典メモ | uspto-grants-2014_02 |