Pivalic acid 6-{2-[(3-fluoro-4-hydroxybenzoyl)isopropylamino]-4-methoxyphenyl)-5,6,7,8-tetrahydronaphthalen-2-yl ester → 6-{2-{{3-Fluoro-4-[2-(4-methyl-[1,4]diazepan-1-yl)ethoxy]benzyl}isopropylamino}-4-methoxyphenyl}-5,6,7,8-tetrahydronaphthalen-2-ol

HRID 2423941ノート

反応式

HRID 2423941 の反応式
[F:1][C:2]1[CH:3]=[C:4]([CH:36]=[CH:37][C:38]=1[OH:39])[C:5]([N:7]([CH:33]([CH3:35])[CH3:34])[C:8]1[CH:13]=[C:12]([O:14][CH3:15])[CH:11]=[CH:10][C:9]=1[CH:16]1[CH2:25][CH2:24][C:23]2[CH:22]=[C:21]([O:26]C(=O)C(C)(C)C)[CH:20]=[CH:19][C:18]=2[CH2:17]1)=O.C(O[C:45]([N:47]1[CH2:53][CH2:52][CH2:51][N:50]([C:54](=O)[CH2:55]Cl)[CH2:49][CH2:48]1)=O)(C)(C)C>>[F:1][C:2]1[CH:3]=[C:4]([CH:36]=[CH:37][C:38]=1[O:39][CH2:55][CH2:54][N:50]1[CH2:51][CH2:52][CH2:53][N:47]([CH3:45])[CH2:48][CH2:49]1)[CH2:5][N:7]([CH:33]([CH3:34])[CH3:35])[C:8]1[CH:13]=[C:12]([O:14][CH3:15])[CH:11]=[CH:10][C:9]=1[CH:16]1[CH2:17][CH2:18][C:23]2[CH:22]=[C:21]([OH:26])[CH:20]=[CH:19][C:24]=2[CH2:25]1

参加物

3

反応物 2

HCID 57934527Pivalic acid 6-{2-[(3-fluoro-4-hydroxybenzoyl)isopropylamino]-4-methoxyphenyl)-5,6,7,8-tetrahydronaphthalen-2-yl esterHCID 57934585Tert-butyl 4-(2-chloroacetyl)-1,4-diazepane-1-carboxylate

生成物 1

HCID 579339406-{2-{{3-Fluoro-4-[2-(4-methyl-[1,4]diazepan-1-yl)ethoxy]benzyl}isopropylamino}-4-methoxyphenyl}-5,6,7,8-tetrahydronaphthalen-2-ol収率 59.3%

実験手順

Synthesized from pivalic acid 6-{2-[(3-fluoro-4-hydroxybenzoyl)isopropylamino]-4-methoxyphenyl}-5,6,7,8-tetrahydronaphthalen-2-yl ester (25 mg) and 4-(2-chloroacetyl)-[1,4]diazepane-1-carboxylic acid tert-butyl ester (26 mg) according to an analogous synthetic method to Example 404 and purified by LC-MS, the title compound (16 mg) was obtained.

後処理

  1. custompurified by LC-MS

出典と根拠

ORDレコード
ord-7dcddceb7e5d4cefb74f246113d42c08
出典データセット
uspto-grants-2011_06
特許番号
US07960412B2

反応ノート

読み込み中…