4-Benzyloxybenzylamine → (4-Benzyloxybenzyl)[6-methoxy-2-(4-methoxyphenyl)indan-4-yl]methylamine

HRID 2424200ノート

反応式

HRID 2424200 の反応式
FC(F)(F)S(O[C:7]1[CH:15]=[C:14]([O:16][CH3:17])[CH:13]=[C:12]2[C:8]=1[CH2:9][CH:10]([C:18]1[CH:23]=[CH:22][C:21]([O:24][CH3:25])=[CH:20][CH:19]=1)[CH2:11]2)(=O)=O.C(OC1C=CC(CN)=CC=1)C1C=CC=CC=1.[CH2:44]([O:51][C:52]1[CH:78]=[CH:77][C:55]([CH2:56][NH:57][C:58]2C=C(OC)C=C3C=2CC(C2C=CC(OC)=CC=2)C3)=[CH:54][CH:53]=1)[C:45]1[CH:50]=[CH:49][CH:48]=[CH:47][CH:46]=1>>[CH2:44]([O:51][C:52]1[CH:53]=[CH:54][C:55]([CH2:56][NH:57][CH2:58][C:7]2[CH:15]=[C:14]([O:16][CH3:17])[CH:13]=[C:12]3[C:8]=2[CH2:9][CH:10]([C:18]2[CH:23]=[CH:22][C:21]([O:24][CH3:25])=[CH:20][CH:19]=2)[CH2:11]3)=[CH:77][CH:78]=1)[C:45]1[CH:46]=[CH:47][CH:48]=[CH:49][CH:50]=1

参加物

4

反応物 3

HCID 42928454-BenzyloxybenzylamineHCID 230872886-Methoxy-2-(4-methoxyphenyl)indan-4-yl trifluoromethanesulfonateHCID 66627646(4-Benzyloxybenzyl)[6-methoxy-2-(4-methoxyphenyl)indan-4-yl]amine

生成物 1

HCID 66626750(4-Benzyloxybenzyl)[6-methoxy-2-(4-methoxyphenyl)indan-4-yl]methylamine

実験手順

Synthesized from 6-methoxy-2-(4-methoxyphenyl)indan-4-yl trifluoromethanesulfonate and 4-benzyloxybenzylamine according to an analogous synthetic method to Example 116, (4-benzyloxybenzyl)[6-methoxy-2-(4-methoxyphenyl)indan-4-yl]amine (1.2 g) was used according to an analogous synthetic method to Preparation Example 18 to provide the title compound (1.0 g).

後処理

  1. customwas used according to an analogous synthetic method to Preparation Example 18

出典と根拠

ORDレコード
ord-4ead3ed18a944e2f8eada496df07229c
出典データセット
uspto-grants-2011_06
特許番号
US07960412B2

反応ノート

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