Hydrochloric Acid → HCID 67246066、化合物

反応式

[CH3:1][C@H:2]1[NH:7][C@@H:6]([CH3:8])[CH2:5][N:4]([CH2:9][C:10]2[CH:14]=[CH:13][N:12]([C:15]3[C:16]([N:21]4[CH2:26][CH2:25][CH:24]([NH:27][C:28]5[CH:33]=[CH:32][C:31]([F:34])=[CH:30][CH:29]=5)[CH2:23][CH2:22]4)=[N:17][CH:18]=[CH:19][CH:20]=3)[N:11]=2)[CH2:3]1.[ClH:35].C(OCC)C>C(Cl)Cl>[ClH:35].[CH3:1][C@H:2]1[NH:7][C@@H:6]([CH3:8])[CH2:5][N:4]([CH2:9][C:10]2[CH:14]=[CH:13][N:12]([C:15]3[C:16]([N:21]4[CH2:22][CH2:23][CH:24]([NH:27][C:28]5[CH:33]=[CH:32][C:31]([F:34])=[CH:30][CH:29]=5)[CH2:25][CH2:26]4)=[N:17][CH:18]=[CH:19][CH:20]=3)[N:11]=2)[CH2:3]1

参加物

実験手順

E1 (0.42 g, 0.91 mmol) was taken up in DCM (10 ml) and 1.2M HCl in diethylether (0.76 ml, 0.91 mmol) was added. Removal of the solvent in vacuo yielded the title compound as a yellow solid (0.45 g), δH (DMSO-d6) 1.08 (6H, d), 1.83 (2H, d), 2.07 (2H, br t), 2.72 (2H, t), 2.95 (2H, br d), 3.16 (2H, d), 3.25 (3H, br s), 3.64 (2H, s), 5.38 (1H, br d), 6.45 (1H, s), 6.56 (2H, br s), 6.88 (2H, t), 7.03 (1H, m), 7.69 (1H, d), 8.12 (1H, s), 8.26 (2H, m), 9.09 (1H, br s).