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HRID 2424619作成日：2026年10月27日

Aminopyridazine → 6-[4-(2-TRIFLUOROMETHYLBENZOYL)PIPERAZIN-1-YL]PYRIDAZINE-3-CARBOXYLIC Acid PYRIDAZIN-3-YLAMIDE

https://huagongshe.com/reaction/2424619

反応式

関与物質

役割名称HCID仕込み量
反応物AminopyridazineHCID 230373—
反応物6-{4-[2-(Trifluoromethyl)benzoyl]piperazin-1-yl}pyridazine-3-carbonyl chlorideHCID 86597230—
生成物6-[4-(2-TRIFLUOROMETHYLBENZOYL)PIPERAZIN-1-YL]PYRIDAZINE-3-CARBOXYLIC Acid PYRIDAZIN-3-YLAMIDEHCID 16036441—

反応手順

Following the procedure of Example 28, making variations only as required to use pyridazin-3-ylamine in place of 2-aminopyridine to react with 6-[4-(2-trifluoromethylbenzoyl)-piperazin-1-yl]pyridazine-3-carbonyl chloride, the title compound was obtained as a white powder (17.3% yield). 1H NMR (300 MHz, CDCl3) δ 10.81, 9.05, 8.70, 8.13, 7.87-7.57, 7.39, 6.95, 4.16-3.80, 3.40. C NMR (300 MHz, CDCl3) δ 167.7, 162.3, 160.1, 148.6, 144.1, 132.4, 129.6, 128.1,

情報源と証拠

DOI10.6084/m9.figshare.5104873.v1
特許番号US07964591B2
出典データセットuspto-grants-2011_06
ORD IDord-3f2bfbc04eb14d18be73fb69b44061dc
出典メモuspto-grants-2011_06