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HRID 242469作成日：2026年10月26日

1,4-Dioxaspiro[4.5]decan-8-one → (S)-3'-(3,4-difluorophenyl)-N-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-6',7'-dihydrospiro[[1,3]dioxolane-2,5'-indazole]-1'(4'H)-carboxamide

https://huagongshe.com/reaction/242469

反応式

関与物質

役割名称HCID仕込み量
反応物1,4-Dioxaspiro[4.5]decan-8-oneHCID 567415—
反応物(S)-3-(3,4-difluorophenyl)-N-(3,3-dimethyl-1-(methyl-amino)-1-oxobutan-2-yl)-6,7-dihydropyrano[4,3-c]pyrazole-1(4H)-carboxamideHCID 46834697—
生成物(S)-3'-(3,4-difluorophenyl)-N-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-6',7'-dihydrospiro[[1,3]dioxolane-2,5'-indazole]-1'(4'H)-carboxamideHCID 46863561—

反応手順

Compound 63 was prepared according to the procedure described for the synthesis of compound 28 by replacing tetrahydro-4H-pyran-4-one with 1,4-dioxaspiro[4.5]decan-8-one in the synthesis of intermediate 16. LCMS (+ESI) m/z=463.2 [M+H]+.

情報源と証拠

DOI10.6084/m9.figshare.5104873.v1
特許番号US08653127B2
出典データセットuspto-grants-2014_02
ORD IDord-c9207b47074646b6868c0269712be68e
出典メモuspto-grants-2014_02