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(2S)-2-Amino-3,3-dimethyl-1-butanol → (S)-3-(2,5-difluorophenyl)-N-(1-hydroxy-3,3-dimethylbutan-2-yl)-5-methyl-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridine-1-carboxamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | (2S)-2-Amino-3,3-dimethyl-1-butanol | HCID 2734079 | — |
| 反応物 | (S)-3-(2,5-difluorophenyl)-N-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-5-methyl-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridine-1-carboxamide | HCID 59345319 | — |
| 生成物 | (S)-3-(2,5-difluorophenyl)-N-(1-hydroxy-3,3-dimethylbutan-2-yl)-5-methyl-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridine-1-carboxamide | HCID 46862675 | — |
反応手順
Compound 66 was prepared according to the procedure described for the synthesis of compound 64 by replacing tert-leucine methylamide with tert-leucinol. LCMS (+ESI) m/z=393.3 [M+H]+.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08653127B2 |
| 出典データセット | uspto-grants-2014_02 |
| ORD ID | ord-e36008064eeb4e7dbd22fcff7646e1d0 |
| 出典メモ | uspto-grants-2014_02 |