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HRID 242475作成日：2026年10月27日

(R)-beta-aminophenethyl alcohol → (R)-N-(2-hydroxy-1-phenylethyl)-5-methyl-3-(2,4,5-trifluorophenyl)-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridine-1-carboxamide

https://huagongshe.com/reaction/242475

反応式

関与物質

役割名称HCID仕込み量
反応物(R)-beta-aminophenethyl alcoholHCID 2724025—
反応物(S)-N-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-5-methyl-3-(2,4,5-trifluorophenyl)-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridine-1-carboxamideHCID 46863441—
生成物(R)-N-(2-hydroxy-1-phenylethyl)-5-methyl-3-(2,4,5-trifluorophenyl)-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridine-1-carboxamideHCID 46861921—

反応手順

Compound 70 was prepared according to the procedure described for the synthesis of compound 37 by replacing tert-leucine methylamide with (R)-2-amino-2-phenylethanol. LCMS (+ESI) m/z=431.2 [M+H]+.

情報源と証拠

DOI10.6084/m9.figshare.5104873.v1
特許番号US08653127B2
出典データセットuspto-grants-2014_02
ORD IDord-eeb770535cec4d84a4178574c37732ef
出典メモuspto-grants-2014_02