5-amino-1-(2-methoxyphenyl)-1H-pyrazole-4-carbonitrile → 5-Amino-1-(4,4-difluorocyclohexyl)-1h-pyrazole-4-carbonitrile

反応式

[NH2:1][C:2]1N(C2C=CC=CC=2OC)[N:5]=[CH:4][C:3]=1[C:15]#N.[F:17][C:18]1([F:26])[CH2:23][CH2:22][CH:21]([NH:24][NH2:25])[CH2:20][CH2:19]1>>[NH2:5][C:4]1[N:24]([CH:21]2[CH2:22][CH2:23][C:18]([F:26])([F:17])[CH2:19][CH2:20]2)[N:25]=[CH:15][C:3]=1[C:2]#[N:1]

参加物

反応物 2

HCID 121505605-amino-1-(2-methoxyphenyl)-1H-pyrazole-4-carbonitrile

HCID 55279041(4,4-Difluorocyclohexyl)hydrazine

生成物 1

HCID 584166835-Amino-1-(4,4-difluorocyclohexyl)-1h-pyrazole-4-carbonitrile

実験手順

Following the procedure for the preparation of 5-amino-1-(2-methoxyphenyl)-1H-pyrazole-4-carbonitrile but substituting 1-(4,4-difluorocyclohexyl)hydrazine provided the title compound. 400 MHz 1H NMR (CDCl3) δ 7.5 (m, 1H), 3.90 (m, 1H), 2.40-1.00 (m, 8H).

出典と根拠

ORDレコード: ord-d46b4b39ca9c4d09a0195c3ffb219a66
出典データセット: uspto-grants-2011_06
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US07964607B2

反応ノート

読み込み中…

参加物